METABOLOMIC TESTING
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What is Metabolomics?
Metabolomics is defined as the comprehensive analysis of small molecules called metabolites present in the cells, biofluids, tissues or organisms. Metabolomics provides a comprehensive profile of the metabolites, evaluates patterns related to the core biological systems and offers insight in to the biochemical dysfunction that may need attention.
It is an emerging technology that holds promise to enable the practice of precision medicine at different levels such as, characterization of metabolic disturbance that underlie disease, discovery of new therapeutic targets and biomarkers that can help with diagnosis and disease prevention.
Precision Medicine is an emerging approach for disease management (treatment and prevention) that takes in account variability in genes, environment and lifestyle for each individual.
The two main analytical platforms used for metabolomics are Nuclear Magnetic Resonance (NMR) Spectroscopy and Mass Spectrometry (MS).
- In NMR Spectroscopy, a compound placed in the magnetic field absorbs radiation and each of its’ isotope resonates at a frequency. A collection of peaks at different positions and intensities for each compound is formed which is unique for each compound and is referred to as the NMR spectrum. It provides structural details about the compound which helps in the identification of the unknown metabolites.
The major drawback of this technique is its low sensitivity. Therefore metabolites present in low abundance may get missed in the analysis.
- In Mass Spectrometry, biomolecules derived from the samples are separated by liquid chromatography (LC) or gas chromatography (GC). The mass to charge ratio of the ions derived by fragmenting the ionized parent compound is determined by mass spectrometry. The mass spectrum is then analysed to identify the key metabolites using bioinformatic tools.
This technique can be linked to liquid or gas chromatography.
- Liquid Chromatography – Mass Spectrometry (LC-MS)
It is an analytical chemistry technique that utilises the separation capabilities of liquid chromatography (LC) and mass analysis capabilities of mass spectrometry (MS). It is a highly sensitive technique and has applications across a wide range of industries including biotechnology, pharmaceutical, agrochemical and cosmetic industry.
The analyte (mix of liquids) is separated using liquid chromatography into different components followed by mass spectrometry that provides spectral information to help identify or confirm each of the separated components.
- Gas Chromatography – Mass Spectrometry (GC-MS)
Historically considered as the gold standard for analyzing biochemical compounds such as lipids, proteins and drug metabolites. It is composed of two main components: Gas Chromatography (GC) and Mass Spectrometry (MS). Gas chromatography is technique used for separating compounds that can easily be vaporized without decomposition. Once separated, the coupled mass spectrometer identifies the different separated and eluted substances based on the MS principle described above. One of the advantages of GC-MS is the reproducible fragmentation pattern for each metabolite which allows for easy identification based on known metabolite patterns stored in a database.
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Types of Laboratory Testing
Intrinsic Analytics provides biochemical analysis of multiple matrices to analyze various metabolites associated with wellness and disease.
Cardiac Health Panel (Apo B, CRP-hs, Lipids, LPA, VLDL)
A comprehensive evaluation of key markers that influence heart function and cardiovascular risk. This panel helps identify early signs of heart disease and supports proactive heart-health management.
Celiac Screening
A targeted blood test that checks for specific antibodies linked to celiac disease. It helps identify whether your immune system is reacting to gluten, guiding the need for further diagnostic testing.
Celiac Panel
A more complete assessment for suspected celiac disease, measuring multiple antibodies to evaluate your body’s sensitivity to gluten. This panel provides stronger clinical insight for diagnosis and ongoing monitoring.
Electrolytes
This test measures essential minerals—such as sodium, potassium, and chloride—that regulate hydration, nerve function, and muscle health. It’s key for assessing balance, especially during illness, intense activity, or medication use.
Fatigue Panel
A multi-marker panel designed to uncover common biochemical causes of persistent tiredness. It evaluates hormones, nutrients, and metabolic indicators to help pinpoint the root of low energy.
Hepatic Function
A detailed assessment of liver enzymes and proteins that reflect liver health, detoxification ability, and inflammation. It’s useful for monitoring liver conditions, medication effects, or general wellness.
Hormone Panel
This test measures critical hormones that influence mood, metabolism, stress response, and reproductive health. It’s ideal for understanding imbalances that may impact energy, sleep, weight, or overall well-being.
Metabolic Panel
A broad overview of your body’s chemical processes, including kidney function, blood sugar, and electrolytes. It helps detect metabolic issues early and supports whole-body wellness planning.
Metals Panel
A specialized test that analyzes levels of heavy and essential metals in the body. It helps detect toxic exposures and ensures your mineral levels support optimal cellular function.
Nutrient Panel
A comprehensive assessment of key vitamins and minerals involved in energy, immunity, and overall health. It
helps identify deficiencies that may be affecting your daily performance or long-term wellness.
Renal Panel
This panel evaluates markers that reflect kidney filtration, hydration balance, and waste removal. It’s important for detecting kidney issues early and monitoring ongoing kidney health.
Sexual Health Panel
A confidential, all-in-one screening for common sexually transmitted infections and reproductive health
markers. It provides clarity, peace of mind, and guidance for treatment or prevention.
Thyroid Panel
A complete evaluation of thyroid hormone levels to assess how well your thyroid is regulating metabolism and energy. It helps identify underactive or overactive thyroid function and supports personalized treatment plans.
Urinalysis
A routine but powerful test that examines various components of urine to assess kidney health, hydration, and metabolic status. It’s often used for early detection of infection, metabolic disorders, or organ stress.
Weight Loss Monitoring Panel
A targeted group of tests that measure metabolic, hormonal, and nutritional markers influencing weight change. It provides actionable insights to support safe, effective, and personalized weight management strategies.
Contact Us
Intrinsic Analytics is Manitoba’s premier bioinformation services company. We provide personalized and customizable bioinformation and biochemical analysis for individuals, commercial enterprises and government agencies. We offer two main platforms, occupational health and personal health. In addition, we engage in health research aimed at developing new health related assays.